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A Murine Model of Myocardial Ischemia-Reperfusion Injury.
Xu, Zhaobin; McElhanon, Kevin E; Beck, Eric X; Weisleder, Noah.
Affiliation
  • Xu Z; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • McElhanon KE; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Beck EX; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Weisleder N; Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, Ohio State University Wexner Medical Center, Columbus, OH, USA. noah.weisleder@osumc.edu.
Methods Mol Biol ; 1717: 145-153, 2018.
Article in En | MEDLINE | ID: mdl-29468590
ABSTRACT
Ligation of the left anterior descending (LAD) coronary artery in the mouse heart is a widely used model to simulate myocardial infarction and ischemia-reperfusion injury. Here we describe a ligation technique routinely performed in our laboratory to induce myocardial infarction that may be used to study ischemia-reperfusion injury in the myocardium. The methods described enhance location of the LAD coronary artery to allow for accurate ligation, thus increasing reproducibility of infarct size and location.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocardial Reperfusion Injury Limits: Animals / Humans Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2018 Document type: Article Affiliation country: United States Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocardial Reperfusion Injury Limits: Animals / Humans Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2018 Document type: Article Affiliation country: United States Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA