Definitive re-irradiation using intensity-modulated radiation therapy in cancers of the head and neck, focusing on rare tumors.
Acta Otolaryngol
; 138(8): 750-758, 2018 Aug.
Article
in En
| MEDLINE
| ID: mdl-29468910
ABSTRACT
PURPOSE:
To analyze the outcomes following re-irradiation for local recurrence of rare head and neck tumors. MATERIAL ANDMETHODS:
We retrospectively analyzed 11 patients who had received intensity-modulated radiation therapy (IMRT) for recurrent tumors in the head and neck except for laryngopharynx.RESULTS:
Primary tumor sites included the maxillary sinus, nasal cavity, and external ear canal in six, three, and two patients, respectively. The median follow-up times were 13 (range, 3-54) months. The median survival time was 17 months with 1- and 2-year survival rates of 63.64 and 39.77%, respectively. Among 11 patients, five experienced local failure in the follow-up period. The 1- and 2-year local control rates were 58 and 47%, respectively. Patients who had received a radiation dose of ≥3 Gy per fraction showed significantly better local control than those receiving less (p = .0419). One patient experienced Grade 3 facial pain as acute toxicity. Late toxicities included radiographic findings of partial central nervous system necrosis in three patients and Grade 3 osteonecrosis and Grade 3 facial nerve disorder in one patient.CONCLUSIONS:
Re-irradiation of rare head and neck tumors using IMRT for loco-regional recurrence may be an acceptable treatment option.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma
/
Esthesioneuroblastoma, Olfactory
/
Head and Neck Neoplasms
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Acta Otolaryngol
Year:
2018
Document type:
Article
Affiliation country:
Japan