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Angiogenic potential of YKL-40 in the dynamics of tumor niche.
Pouyafar, Ayda; Heydarabad, Milad Zadi; Mahboob, Soltanali; Mokhtarzadeh, Ahad; Rahbarghazi, Reza.
Affiliation
  • Pouyafar A; Department of Biochemistry, Higher Education Institute of Rab-Rashid, Tabriz, Iran.
  • Heydarabad MZ; Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Mahboob S; Department of Biochemistry, Higher Education Institute of Rab-Rashid, Tabriz, Iran.
  • Mokhtarzadeh A; Department of Biochemistry, Higher Education Institute of Rab-Rashid, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Rahbarghazi R; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: rahbarghazir@tbzmed.ac.ir.
Biomed Pharmacother ; 100: 478-485, 2018 Apr.
Article in En | MEDLINE | ID: mdl-29477911
ABSTRACT
A multitude of clinical studies showed the elevation of YKL-40 in subjects with different kinds of tumors. It is predicted that an inherent correlation exists between survivals of cancer patients with total YKL-40 serum levels, making this factor as a potential novel biomarker. However, the crucial role of YKL-40 in the dynamics of cancers, especially angiogenesis, has not yet been completely addressed. In this review, we highlighted the various facets of YKL-40 and its importance in cancer biology as a bio-shuttle in gene therapy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers, Tumor / Growth Substances / Chitinase-3-Like Protein 1 / Neoplasms / Neovascularization, Pathologic Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biomed Pharmacother Year: 2018 Document type: Article Affiliation country: Iran
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers, Tumor / Growth Substances / Chitinase-3-Like Protein 1 / Neoplasms / Neovascularization, Pathologic Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biomed Pharmacother Year: 2018 Document type: Article Affiliation country: Iran