Impact of Bacille Calmette-Guérin revaccination on serum IgE levels in a randomized controlled trial.
Rev Soc Bras Med Trop
; 51(1): 94-98, 2018.
Article
in En
| MEDLINE
| ID: mdl-29513852
ABSTRACT
INTRODUCTION:
Bacille Calmette-Guérin (BCG) downmodulates allergen-specific IgE levels and prevents other atopic responses in experimental models but fails to protect against respiratory allergies. Human responsiveness to BCG is variable and may interfere with protection.METHODS:
Multivariate models were evaluated to test the possible effect of responsiveness (assessed by IFN-γ production) to BCG revaccination on the modulation of total and allergen-specific serum IgE levels in healthy volunteers participating in a randomized controlled trial.RESULTS:
Serum total or Derp-specific IgE levels did not change regardless of the increase in IFN-γ levels.CONCLUSIONS:
BCG responsiveness does not affect protection against atopy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulin E
/
BCG Vaccine
/
Immunization, Secondary
/
Interferon-gamma
Type of study:
Clinical_trials
/
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Rev Soc Bras Med Trop
Year:
2018
Document type:
Article
Affiliation country:
Brazil