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Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone.
Perron, Amelie; Nishikawa, Yoshihiro; Iwata, Jun; Shimojo, Hiromi; Takaya, Junichiro; Kobayashi, Kumiko; Imayoshi, Itaru; Mbenza, Naasson M; Takenoya, Mihoko; Kageyama, Ryoichiro; Kodama, Yuzo; Uesugi, Motonari.
Affiliation
  • Perron A; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Uji, Kyoto 611-0011.
  • Nishikawa Y; Department of Gastroenterology and Hepatology, Graduate School of Medicine.
  • Iwata J; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011.
  • Shimojo H; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Uji, Kyoto 611-0011; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
  • Takaya J; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011.
  • Kobayashi K; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
  • Imayoshi I; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan; Graduate School of Biostudies, Kyoto University, Kyoto 606-8507, Japan.
  • Mbenza NM; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011.
  • Takenoya M; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Uji, Kyoto 611-0011.
  • Kageyama R; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Uji, Kyoto 611-0011; Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
  • Kodama Y; Department of Gastroenterology and Hepatology, Graduate School of Medicine. Electronic address: kodamayu@kuhp.kyoto-u.ac.jp.
  • Uesugi M; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Uji, Kyoto 611-0011. Electronic address: uesugi@scl.kyoto-u.ac.jp.
J Biol Chem ; 293(21): 8285-8294, 2018 05 25.
Article in En | MEDLINE | ID: mdl-29523683
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Repressor Proteins / Apoptosis / Small Molecule Libraries / High-Throughput Screening Assays / Transcription Factor HES-1 / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Animals / Female / Humans Language: En Journal: J Biol Chem Year: 2018 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Repressor Proteins / Apoptosis / Small Molecule Libraries / High-Throughput Screening Assays / Transcription Factor HES-1 / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Animals / Female / Humans Language: En Journal: J Biol Chem Year: 2018 Document type: Article Country of publication: United States