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Synthesis and HNO Donating Properties of the Piloty's Acid Analogue Trifluoromethanesulphonylhydroxamic Acid: Evidence for Quantitative Release of HNO at Neutral pH Conditions.
Adas, Sonya K; Bharadwaj, Vinay; Zhou, Yang; Zhang, Jiuhong; Seed, Alexander J; Brasch, Nicola E; Sampson, Paul.
Affiliation
  • Adas SK; Department of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.
  • Bharadwaj V; School of Science, Auckland University of Technology, Private Bag 92006, Auckland, 1142, New Zealand.
  • Zhou Y; Department of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.
  • Zhang J; Department of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.
  • Seed AJ; Department of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.
  • Brasch NE; School of Science, Auckland University of Technology, Private Bag 92006, Auckland, 1142, New Zealand.
  • Sampson P; Department of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.
Chemistry ; 24(29): 7330-7334, 2018 May 23.
Article in En | MEDLINE | ID: mdl-29527748
ABSTRACT
Trifluoromethanesulphonylhydroxamic acid, CF3 SO2 NHOH, is shown to release HNO under physiological pH conditions. A two-step synthesis is presented with the first complete characterization of CF3 SO2 NHOH. This molecule rapidly decomposes in neutral aqueous solution to cleanly release HNO and CF3 SO2- , which was demonstrated using the HNO traps TXPTS and HOCbl, and by 19 F NMR spectroscopy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: United States