Could OX40 agonist antibody promote activation of the anti-tumor immune response in gastric cancer?
J Surg Oncol
; 117(5): 840-844, 2018 Apr.
Article
in En
| MEDLINE
| ID: mdl-29529339
ABSTRACT
BACKGROUND AND OBJECTIVES:
OX40, a membrane-bound molecule of the tumor-necrosis-factor-receptor superfamily, is a critical costimulatory receptor during the immune response, especially to T cells, but studies described their presence of OX-40 on neutrophils and monocytes, suggesting a potential role in the activation of immune response. Our aim was to characterize costimulatory receptors OX40 expression on circulating leukocytes in gastric cancer to identify novel targets for immunotherapy.METHODS:
Peripheral blood mononuclear cells were isolated from 24 gastric cancer patients and 34 healthy controls and the expression of costimulatory (OX40) receptors were analyzed on T cells, neutrophil and monocyte using monoclonal antibodies by flow cytometry.RESULTS:
We found that the higher levels of OX40 + T cells, monocytes/OX40+ and neutrophils/OX40+ from gastric cancer patients when compared to controls (P < 0.0001), and also higher levels of OX40+ T cells when compared to stages III and IV (P = 0.02). Percentage levels of total T cells were similar between patients and controls.CONCLUSIONS:
OX40 as a therapeutic agent has been investigated in many preclinical tumor models. Our findings suggest that of levels of costimulatory in T cells in GC will direct future studies on the role that costimulatory receptors play in the failure of T cell-mediated immunity.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Neoplasms
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Leukocytes, Mononuclear
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Monocytes
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T-Lymphocytes
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Receptors, OX40
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Antibodies, Monoclonal
Type of study:
Observational_studies
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Prognostic_studies
Limits:
Female
/
Humans
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Male
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Middle aged
Language:
En
Journal:
J Surg Oncol
Year:
2018
Document type:
Article
Affiliation country:
Brazil
Publication country:
EEUU
/
ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
/
UNITED STATES
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UNITED STATES OF AMERICA
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US
/
USA