Within-Host Evolution of Human Influenza Virus.
Trends Microbiol
; 26(9): 781-793, 2018 09.
Article
in En
| MEDLINE
| ID: mdl-29534854
ABSTRACT
The rapid global evolution of influenza virus begins with mutations that arise de novo in individual infections, but little is known about how evolution occurs within hosts. We review recent progress in understanding how and why influenza viruses evolve within human hosts. Advances in deep sequencing make it possible to measure within-host genetic diversity in both acute and chronic influenza infections. Factors like antigenic selection, antiviral treatment, tissue specificity, spatial structure, and multiplicity of infection may affect how influenza viruses evolve within human hosts. Studies of within-host evolution can contribute to our understanding of the evolutionary and epidemiological factors that shape influenza virus's global evolution.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Influenza A virus
/
Evolution, Molecular
/
Influenza, Human
/
Host-Pathogen Interactions
Limits:
Humans
Language:
En
Journal:
Trends Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2018
Document type:
Article
Affiliation country:
United States