Transcriptional control of the MUC16 promoter facilitates follicle-stimulating hormone peptide-conjugated shRNA nanoparticle-mediated inhibition of ovarian carcinoma in vivo.

Zhang, Ming-Xing; Hong, Shan-Shan; Cai, Qing-Qing; Zhang, Meng; Chen, Jun; Zhang, Xiao-Yan; Xu, Cong-Jian

Zhang, Ming-Xing; Hong, Shan-Shan; Cai, Qing-Qing; Zhang, Meng; Chen, Jun; Zhang, Xiao-Yan; Xu, Cong-Jian.

Affiliation

Zhang MX; a Obstetrics and Gynecology Hospital , Fudan University , Shanghai , China.
Hong SS; a Obstetrics and Gynecology Hospital , Fudan University , Shanghai , China.
Cai QQ; a Obstetrics and Gynecology Hospital , Fudan University , Shanghai , China.
Zhang M; b Department of Obstetrics and Gynecology of Shanghai Medical School , Fudan University , Shanghai , China.
Chen J; c Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases , Shanghai , China.
Zhang XY; a Obstetrics and Gynecology Hospital , Fudan University , Shanghai , China.
Xu CJ; d Department of Pharmaceutics, School of Pharmacy , Fudan University , Shanghai , China.

Drug Deliv ; 25(1): 797-806, 2018 Nov.

Article in En | MEDLINE | ID: mdl-29542355

Subject(s)

Follicle Stimulating Hormone, beta Subunit/administration & dosage; Membrane Proteins/antagonists & inhibitors; Nanoparticles/chemistry; Ovarian Neoplasms/therapy; Promoter Regions, Genetic; RNA, Small Interfering/administration & dosage; RNAi Therapeutics/methods; Animals; CA-125 Antigen/genetics; CA-125 Antigen/metabolism; Carcinoma/metabolism; Carcinoma/pathology; Carcinoma/therapy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemokine CXCL1/antagonists & inhibitors; Chemokine CXCL1/genetics; Chemokine CXCL1/metabolism; Computational Biology; Female; Follicle Stimulating Hormone, beta Subunit/chemistry; Follicle Stimulating Hormone, beta Subunit/metabolism; Follicle Stimulating Hormone, beta Subunit/therapeutic use; Humans; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Nanoparticles/ultrastructure; Neoplasm Invasiveness/prevention & control; Neoplasm Proteins/antagonists & inhibitors; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; Neoplasm Transplantation; Ovarian Neoplasms/metabolism; Ovarian Neoplasms/pathology; Particle Size; Peptide Fragments/administration & dosage; Peptide Fragments/chemistry; Peptide Fragments/metabolism; Peptide Fragments/therapeutic use; RNA, Small Interfering/metabolism; RNA, Small Interfering/therapeutic use; Surface Properties; Tumor Burden

Key words

MUC16; Ovarian carcinoma; follicle-stimulating hormone; nanoparticle; targeted therapy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Promoter Regions, Genetic / Follicle Stimulating Hormone, beta Subunit / RNA, Small Interfering / Nanoparticles / RNAi Therapeutics / Membrane Proteins Type of study: Prognostic_studies Language: En Journal: Drug Deliv Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2018 Document type: Article Affiliation country: China Country of publication: United kingdom

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