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Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria.
Matic, Stanka; Jiang, Min; Nicholls, Thomas J; Uhler, Jay P; Dirksen-Schwanenland, Caren; Polosa, Paola Loguercio; Simard, Marie-Lune; Li, Xinping; Atanassov, Ilian; Rackham, Oliver; Filipovska, Aleksandra; Stewart, James B; Falkenberg, Maria; Larsson, Nils-Göran; Milenkovic, Dusanka.
Affiliation
  • Matic S; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany.
  • Jiang M; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany.
  • Nicholls TJ; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, 405 30, Sweden.
  • Uhler JP; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, 405 30, Sweden.
  • Dirksen-Schwanenland C; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany.
  • Polosa PL; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, Bari, 70125, Italy.
  • Simard ML; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany.
  • Li X; Proteomics Core Facility, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany.
  • Atanassov I; Proteomics Core Facility, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany.
  • Rackham O; Harry Perkins Institute of Medical Research Centre for Medical Research and School of Molecular Sciences, The University of Western Australia, Nedlands, WA 6009, Australia.
  • Filipovska A; Harry Perkins Institute of Medical Research Centre for Medical Research and School of Molecular Sciences, The University of Western Australia, Nedlands, WA 6009, Australia.
  • Stewart JB; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany.
  • Falkenberg M; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, 405 30, Sweden.
  • Larsson NG; Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, 50931, Germany. nils-goran.larsson@ki.se.
  • Milenkovic D; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden. nils-goran.larsson@ki.se.
Nat Commun ; 9(1): 1202, 2018 03 23.
Article in En | MEDLINE | ID: mdl-29572490
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Progeria / DNA, Mitochondrial / Gene Deletion / Exodeoxyribonucleases Limits: Animals / Female / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2018 Document type: Article Affiliation country: Germany Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Progeria / DNA, Mitochondrial / Gene Deletion / Exodeoxyribonucleases Limits: Animals / Female / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2018 Document type: Article Affiliation country: Germany Country of publication: United kingdom