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Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.
Kiyota, Tomomi; Machhi, Jatin; Lu, Yaman; Dyavarshetty, Bhagyalaxmi; Nemati, Maryam; Yokoyama, Izumi; Mosley, R L; Gendelman, Howard E.
Affiliation
  • Kiyota T; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
  • Machhi J; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
  • Lu Y; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
  • Dyavarshetty B; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
  • Nemati M; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
  • Yokoyama I; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
  • Mosley RL; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
  • Gendelman HE; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address: hegendel@unmc.edu.
J Neuroimmunol ; 319: 80-92, 2018 06 15.
Article in En | MEDLINE | ID: mdl-29573847
ABSTRACT
We investigated the effects of granulocyte-macrophage colony stimulating factor (GM-CSF) on behavioral and pathological outcomes in Alzheimer's disease (AD) and non-transgenic mice. GM-CSF treatment in AD mice reduced brain amyloidosis, increased plasma Aß, and rescued cognitive impairment with increased hippocampal expression of calbindin and synaptophysin and increased levels of doublecortin-positive cells in the dentate gyrus. These data extend GM-CSF pleiotropic neuroprotection mechanisms in AD and include regulatory T cell-mediated immunomodulation of microglial function, Aß clearance, maintenance of synaptic integrity, and induction of neurogenesis. Together these data support further development of GM-CSF as a neuroprotective agent for AD.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Granulocyte-Macrophage Colony-Stimulating Factor / Neuroprotective Agents / Alzheimer Disease Limits: Animals Language: En Journal: J Neuroimmunol Year: 2018 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Granulocyte-Macrophage Colony-Stimulating Factor / Neuroprotective Agents / Alzheimer Disease Limits: Animals Language: En Journal: J Neuroimmunol Year: 2018 Document type: Article Affiliation country: United States