FOXO1 regulates VEGFA expression and promotes angiogenesis in healing wounds.
J Pathol
; 245(3): 258-264, 2018 07.
Article
in En
| MEDLINE
| ID: mdl-29574902
ABSTRACT
Angiogenesis is a critical aspect of wound healing. We investigated the role of keratinocytes in promoting angiogenesis in mice with lineage-specific deletion of the transcription factor FOXO1. The results indicate that keratinocyte-specific deletion of Foxo1 reduces VEGFA expression in mucosal and skin wounds and leads to reduced endothelial cell proliferation, reduced angiogenesis, and impaired re-epithelialization and granulation tissue formation. In vitro FOXO1 was needed for VEGFA transcription and expression. In a porcine dermal wound-healing model that closely resembles healing in humans, local application of a FOXO1 inhibitor reduced angiogenesis. This is the first report that FOXO1 directly regulates VEGFA expression and that FOXO1 is needed for normal angiogenesis during wound healing. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin
/
Wound Healing
/
Wounds and Injuries
/
Neovascularization, Physiologic
/
Vascular Endothelial Growth Factor A
/
Forkhead Transcription Factors
/
Forkhead Box Protein O1
/
Gingiva
/
Mouth Mucosa
Type of study:
Prognostic_studies
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
J Pathol
Year:
2018
Document type:
Article
Affiliation country:
United States