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Effect of spleen tyrosine kinase on nonsmall cell lung cancer.
Hao, Ying Tao; Peng, Chuan Liang; Zhao, Yun Peng; Sun, Qi Feng; Zhao, Xiao Gang; Cong, Bo.
Affiliation
  • Hao YT; Department of Thoracic, The Second Hospital of Shandong University, Jinan, Shandong, China.
  • Peng CL; Department of Thoracic, The Second Hospital of Shandong University, Jinan, Shandong, China.
  • Zhao YP; Department of Thoracic, The Second Hospital of Shandong University, Jinan, Shandong, China.
  • Sun QF; Department of Thoracic, The Second Hospital of Shandong University, Jinan, Shandong, China.
  • Zhao XG; Department of Thoracic, The Second Hospital of Shandong University, Jinan, Shandong, China.
  • Cong B; Department of Thoracic, The Second Hospital of Shandong University, Jinan, Shandong, China.
J Cancer Res Ther ; 14(Supplement): S100-S104, 2018.
Article in En | MEDLINE | ID: mdl-29578158
ABSTRACT
AIM OF STUDY To investigate the anti.tumor effect of spleen tyrosine kinase. (Syk) on the human nonsmall cell lung cancer cells in vitro and its mechanism. MATERIALS AND

METHODS:

In this study, we constructed a eukaryotic expression vector pcDNA3.1D/V5-His-TOPO/Syk and transfected it into human nonsmall cell lung cancer cells A549. Then, we not only analyzed the expression of Syk in transfected cells and its invasion but also the expression of matrix metalloproteinase-9 (MMP-9).

RESULTS:

The results showed that overexpressed Syk significantly inhibited A549 cell invasive ability by decreasing the expression of MMP-9.

CONCLUSION:

The overexpressed Syk plays an important role in tumor invasion and metastasis, and a negative role in human nonsmall cell lung cancer cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Syk Kinase / Lung Neoplasms Limits: Humans Language: En Journal: J Cancer Res Ther Journal subject: NEOPLASIAS / TERAPEUTICA Year: 2018 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Syk Kinase / Lung Neoplasms Limits: Humans Language: En Journal: J Cancer Res Ther Journal subject: NEOPLASIAS / TERAPEUTICA Year: 2018 Document type: Article Affiliation country: China