Biomolecular Ultrasound and Sonogenetics.
Annu Rev Chem Biomol Eng
; 9: 229-252, 2018 06 07.
Article
in En
| MEDLINE
| ID: mdl-29579400
ABSTRACT
Visualizing and modulating molecular and cellular processes occurring deep within living organisms is fundamental to our study of basic biology and disease. Currently, the most sophisticated tools available to dynamically monitor and control cellular events rely on light-responsive proteins, which are difficult to use outside of optically transparent model systems, cultured cells, or surgically accessed regions owing to strong scattering of light by biological tissue. In contrast, ultrasound is a widely used medical imaging and therapeutic modality that enables the observation and perturbation of internal anatomy and physiology but has historically had limited ability to monitor and control specific cellular processes. Recent advances are beginning to address this limitation through the development of biomolecular tools that allow ultrasound to connect directly to cellular functions such as gene expression. Driven by the discovery and engineering of new contrast agents, reporter genes, and bioswitches, the nascent field of biomolecular ultrasound carries a wave of exciting opportunities.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ultrasonics
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Annu Rev Chem Biomol Eng
Year:
2018
Document type:
Article