Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster.
Neurobiol Aging
; 66: 149-157, 2018 06.
Article
in En
| MEDLINE
| ID: mdl-29579685
ABSTRACT
The insulin family of growth factors plays an important role in development and function of the nervous system. Reduced insulin and insulin-growth-factor signaling (IIS), however, can improve symptoms of neurodegenerative diseases in laboratory model organisms and protect against age-associated decline in neuronal function. Recently, we showed that chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber escape response circuit. Here, we expand our initial findings by demonstrating that reduced functional output in the giant fiber system of aging flies can be prevented by increasing proteasomal activity within the circuit. Manipulations of IIS in neurons can also affect longevity, underscoring the relevance of the nervous system for aging.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
/
Somatomedins
/
Signal Transduction
/
Synaptic Transmission
/
Intercellular Signaling Peptides and Proteins
/
Proteasome Endopeptidase Complex
/
Insulin
/
Neurons
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Neurobiol Aging
Year:
2018
Document type:
Article
Affiliation country:
United kingdom