Identification of the functional pathways altered by placental cell exposure to high glucose: lessons from the transcript and metabolite interactome.

Hulme, C H; Stevens, A; Dunn, W; Heazell, A E P; Hollywood, K; Begley, P; Westwood, M; Myers, J E

Hulme, C H; Stevens, A; Dunn, W; Heazell, A E P; Hollywood, K; Begley, P; Westwood, M; Myers, J E.

Affiliation

Hulme CH; Maternal and Fetal Health Research Centre, Division of Developmental Biology & Medicine, School of Medical Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, M13 9WL, UK.
Stevens A; Maternal and Fetal Health Research Centre, Central Manchester University Hospitals NHS Foundation Trust, St Mary's Hospital, Manchester Academic Health sciences Centre, Manchester, M13 9WL, UK.
Dunn W; Division of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health University of Manchester, Manchester Academic Health Sciences Centre, Manchester, M13 9WL, UK.
Heazell AEP; Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, M13 9WL, UK.
Hollywood K; Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, Manchester, M13 9WL, UK.
Begley P; School of Biosciences, Phenome Centre Birmingham and Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, UK.
Westwood M; Maternal and Fetal Health Research Centre, Division of Developmental Biology & Medicine, School of Medical Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, M13 9WL, UK.
Myers JE; Maternal and Fetal Health Research Centre, Central Manchester University Hospitals NHS Foundation Trust, St Mary's Hospital, Manchester Academic Health sciences Centre, Manchester, M13 9WL, UK.

Sci Rep ; 8(1): 5270, 2018 03 27.

Article in En | MEDLINE | ID: mdl-29588451

Subject(s)

Glucose/metabolism; Hyperglycemia/metabolism; Metabolome; Placenta/metabolism; Transcriptome; Animals; Cell Line; Diabetes Complications/genetics; Diabetes Complications/metabolism; Diabetes Mellitus/genetics; Diabetes Mellitus/metabolism; Female; Gene Expression Profiling; Gene Regulatory Networks; Humans; Hyperglycemia/genetics; Lipid Metabolism; Mice; Pregnancy; Pregnancy Complications/genetics; Pregnancy Complications/metabolism; Trophoblasts/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Placenta / Metabolome / Transcriptome / Glucose / Hyperglycemia Type of study: Diagnostic_studies Limits: Animals / Female / Humans / Pregnancy Language: En Journal: Sci Rep Year: 2018 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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