Engineering a Dual Small Molecule Gated ZAP70 Switch in T Cells.

Wong, Nicole M L; Wong, Wilson W

Wong, Nicole M L; Wong, Wilson W.

Affiliation

Wong NML; Department of Biomedical Engineering , Boston University , Boston , Massachusetts 02215 , United States.
Wong WW; Biological Design Center , Boston University , Boston , Massachusetts 02215 , United States.

ACS Synth Biol ; 7(4): 969-977, 2018 04 20.

Article in En | MEDLINE | ID: mdl-29589904

Subject(s)

Recombinant Fusion Proteins/metabolism; T-Lymphocytes/drug effects; T-Lymphocytes/metabolism; ZAP-70 Protein-Tyrosine Kinase/metabolism; Calcium/metabolism; Cytokines/metabolism; HEK293 Cells; Humans; Protein Domains; Protein Engineering/methods; Pyrimidines/pharmacology; Receptors, Antigen, T-Cell/metabolism; Receptors, Chimeric Antigen/metabolism; Receptors, Estrogen/genetics; Receptors, Estrogen/metabolism; Recombinant Fusion Proteins/genetics; Signal Transduction; Tamoxifen/analogs & derivatives; Tamoxifen/pharmacology; ZAP-70 Protein-Tyrosine Kinase/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / T-Lymphocytes / ZAP-70 Protein-Tyrosine Kinase Limits: Humans Language: En Journal: ACS Synth Biol Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States

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