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Prospective evaluation of serum IL-16 and risk of prostate cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Moore, Amy; Huang, Wen-Yi; Danforth, Kim; Falk, Roni; Meade, Allison; Bagni, Rachel; Berndt, Sonja I.
Affiliation
  • Moore A; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA. amy.moore@nih.gov.
  • Huang WY; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
  • Danforth K; Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.
  • Falk R; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
  • Meade A; Protein Expression Laboratory, Cancer Research and Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Bagni R; Protein Expression Laboratory, Cancer Research and Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
Cancer Causes Control ; 29(4-5): 455-464, 2018 05.
Article in En | MEDLINE | ID: mdl-29594819
BACKGROUND: Sexually transmitted infections and chronic inflammation have been associated with an increased risk of prostate cancer. Inflammatory mediators, such as cytokines and free radicals, have been hypothesized to play a role. METHODS: To explore the role of inflammation in prostate cancer risk further, we examined the association between pre-diagnostic serum levels of interleukin-16 (IL-16), an important pleiotropic cytokine, and prostate cancer risk among 932 Caucasian cases and 942 controls and 154 African-American cases and 302 controls in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Serum IL-16 was quantified using enzyme-linked immunoassay. Logistic regression was used to estimate associations between IL-16 and prostate cancer risk, separately by race. RESULTS: Although no association between IL-16 and prostate cancer overall was observed among Caucasians (p = 0.27), a significantly increased risk of high-grade prostate cancer, defined as Gleason ≥ 7 (phet = 0.02), was observed with increasing levels of IL-16 (OR3rd vs. 1st tertile = 1.37, 95% CI 1.04-1.81, ptrend = 0.02). We also discovered a significant interaction between IL-16 and history of gonorrhea (p = 0.04). Among Caucasian men with a history of gonorrhea, elevated IL-16 levels were associated with an increased risk of prostate cancer (OR3rd vs. 1st tertile = 3.64, 95% CI 1.14-11.6) but no association was seen among those without a history of gonorrhea (OR3rd vs. 1st tertile = 1.06, 95% CI 0.83-1.34). No associations were observed among African-Americans. CONCLUSIONS: This study found evidence that higher pre-diagnostic IL-16 levels may be associated with increased risk of high-grade disease, supporting inflammation as potential mechanism by which sexually transmitted diseases may increase risk.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Interleukin-16 / Inflammation Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Cancer Causes Control Journal subject: EPIDEMIOLOGIA / NEOPLASIAS Year: 2018 Document type: Article Affiliation country: United States Country of publication: Netherlands

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Interleukin-16 / Inflammation Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Cancer Causes Control Journal subject: EPIDEMIOLOGIA / NEOPLASIAS Year: 2018 Document type: Article Affiliation country: United States Country of publication: Netherlands