Postpartum risk of diabetes and predictive factors for glucose intolerance in East Asian women with gestational diabetes.
Diabetes Res Clin Pract
; 140: 1-8, 2018 Jun.
Article
in En
| MEDLINE
| ID: mdl-29596944
ABSTRACT
AIMS:
Women with a history of gestational diabetes mellitus (GDM) are likely to develop postpartum diabetes mellitus (DM). We examined women in the early stages of pregnancy who were at high risk of postpartum DM progression to establish a follow-up method for early detection.METHODS:
We performed the oral glucose tolerance test (OGTT) and identified predictive factors for postpartum impaired glucose tolerance (IGT) or DM in 77 women after GDM, for 2â¯years after delivery, retrospectively. Cutoff values for each factor were determined. We classified these women with GDM into four groups using these predictive factors and evaluated postpartum glucose intolerance (GI) in each group.RESULTS:
In total, 44.1% of the women with a GDM history had developed postpartum GI within 2â¯years. We determined three risk factors for postpartum GI elevated glucose level 120â¯min after a 75-g OGTT (Glu120), elevated glycated hemoglobin (HbA1c) level at diagnosis, and perinatal complications. The cutoff Glu120 and the HbA1c level were 155â¯mg/dl and 5.3% (34â¯mmol/mol), respectively. Type 2 DM developed in 53.8% of women, and IGT developed in 38.5% of women within 2â¯years in groups with high Glu120 and high HbA1c.CONCLUSIONS:
High-risk groups require careful follow-up observation.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diabetes, Gestational
/
Glucose Intolerance
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Diabetes Res Clin Pract
Journal subject:
ENDOCRINOLOGIA
Year:
2018
Document type:
Article
Affiliation country:
Japan