The study of leukocyte phagocytic activity in the presence of herpetic infection and stroke.
Wiad Lek
; 71(1 pt 2): 155-159, 2018.
Article
in En
| MEDLINE
| ID: mdl-29602924
ABSTRACT
OBJECTIVE:
Inrtoduction Post-stroke complications are one of the urgent and insufficiently resolved problems. According to different literature data 23% to 65% of patients suffer from the post-stroke development of an infectious process. Herpes simplex virus type 1 and 2 can also be etiological factors of stroke development, however their reactivation is seldom mentioned in clinical observations. The development of immune suppression is considered to be the cause of these complications. Theaim:
The current study aims at determining post-stroke changes in leukocyte component of the immunity and in the presence of concomitant herpetic infection as well as at finding changes in phagocytosis parameters during antiviral treatment. PATIENTS ANDMETHODS:
Materials andmethods:
The experiments were carried out on mice of the Balb/Ñ line. The animals were infected with the herpes simplex virus type I, and 30 days later hemorrhagic stroke was simulated by administering 0.1 ml of autoblood into the right hemisphere. Following the acute stroke some animals were given acyclovir, proteflazid or altabor. From the animals' blood leukocytes were obtained and phagocytic activity and production of reactive oxygen species of granulocytes and agranulocytes in relation to fluorescent E.coli bacteria were studied by flow cytometry.RESULTS:
Results:
The experiment revealed significant changes in the redistribution between two major types of leukocytes in mice with stroke (an increased number of agranulocytes by 19.9%) and decreased phagocytosis activity, in the animals infected with herpes simplex virus type Ð in particular. Ischemic brain damage had an immunosuppressive effect on blood leukocytes. For comparison a significant increase in phagocyte count in leukocytes was found in the case of viral infection. The use of drugs with antiviral effects did not affect the activity of granulocytes / agranulocytes.CONCLUSION:
Conclusion:
Stroke can be the cause of latent herpes virus infection reactivation and has essential negative effect on immune characteristics of leukocytes that remain unchanged with the use of antiviral agents.Key words
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Phagocytosis
/
Stroke
/
Herpes Simplex
/
Leukocytes
Limits:
Animals
Language:
En
Journal:
Wiad Lek
Journal subject:
MEDICINA
Year:
2018
Document type:
Article
Affiliation country:
Ukraine