Isovitexin alleviates liver injury induced by lipopolysaccharide/d-galactosamine by activating Nrf2 and inhibiting NF-&#954;B activation.

Hu, Jian-Jian; Wang, Hui; Pan, Chen-Wei; Lin, Meng-Xiang

Isovitexin alleviates liver injury induced by lipopolysaccharide/d-galactosamine by activating Nrf2 and inhibiting NF-κB activation.

Hu, Jian-Jian; Wang, Hui; Pan, Chen-Wei; Lin, Meng-Xiang.

Affiliation

Hu JJ; Department of Anesthesiology, Critical Care and Pain Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
Wang H; Department of Gastroenterology, The Affiliated YanAn Hospital of Kunming Medical University, Kunming, Yunnan, 650051, China.
Pan CW; Department of Infectious Disease, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, PR China.
Lin MX; Department of Anesthesiology, Critical Care and Pain Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China. Electronic address: linmengxiang11@yeah.net.

Microb Pathog ; 119: 86-92, 2018 Jun.

Article in En | MEDLINE | ID: mdl-29604422

Subject(s)

Apigenin/pharmacology; Chemical and Drug Induced Liver Injury/drug therapy; Galactosamine/adverse effects; Lipopolysaccharides/adverse effects; Liver/drug effects; NF-E2-Related Factor 2/metabolism; NF-kappa B/drug effects; Animals; Apigenin/administration & dosage; Carbon Tetrachloride/adverse effects; Galactosamine/administration & dosage; Gene Expression Regulation/drug effects; Heme Oxygenase-1/metabolism; Lipopolysaccharides/administration & dosage; Liver Function Tests; Male; Membrane Proteins/metabolism; Mice; Mice, Inbred BALB C; NF-kappa B/metabolism; Oryza/chemistry; Phosphorylation; Plant Extracts/pharmacology; Signal Transduction/drug effects; Tumor Necrosis Factor-alpha/blood; Up-Regulation

Key words

Acute liver injury; Isovitexin; Lipopolysaccharide; TNF-α

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lipopolysaccharides / NF-kappa B / Apigenin / NF-E2-Related Factor 2 / Chemical and Drug Induced Liver Injury / Galactosamine / Liver Limits: Animals Language: En Journal: Microb Pathog Journal subject: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Year: 2018 Document type: Article Affiliation country: China Country of publication: United kingdom

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