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DPD functional tests in plasma, fresh saliva and dried saliva samples as predictors of 5-fluorouracil exposure and occurrence of drug-related severe toxicity.
Neto, Olavo Vicente; Raymundo, Suziane; Franzoi, Maria Alice; do Carmo Artmann, Andiara; Tegner, Mariane; Müller, Victoria Vendramini; Hahn, Roberta Zilles; Alves, Gustavo Vasconcelos; Schwartsmann, Gilberto; Linden, Rafael; Antunes, Marina Venzon.
Affiliation
  • Neto OV; Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil.
  • Raymundo S; Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil; Laboratory of Analytical Toxicology, Institute of Health Sciences, Universidade Feevale, Novo Hamburgo, RS, Brazil.
  • Franzoi MA; Oncology Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
  • do Carmo Artmann A; Laboratory of Analytical Toxicology, Institute of Health Sciences, Universidade Feevale, Novo Hamburgo, RS, Brazil.
  • Tegner M; Laboratory of Analytical Toxicology, Institute of Health Sciences, Universidade Feevale, Novo Hamburgo, RS, Brazil.
  • Müller VV; Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil; Laboratory of Analytical Toxicology, Institute of Health Sciences, Universidade Feevale, Novo Hamburgo, RS, Brazil.
  • Hahn RZ; Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil; Laboratory of Analytical Toxicology, Institute of Health Sciences, Universidade Feevale, Novo Hamburgo, RS, Brazil.
  • Alves GV; Oncology Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
  • Schwartsmann G; Oncology Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
  • Linden R; Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil; Laboratory of Analytical Toxicology, Institute of Health Sciences, Universidade Feevale, Novo Hamburgo, RS, Brazil.
  • Antunes MV; Graduate Program on Toxicology and Analytical Toxicology, Universidade Feevale, Novo Hamburgo, RS, Brazil; Laboratory of Analytical Toxicology, Institute of Health Sciences, Universidade Feevale, Novo Hamburgo, RS, Brazil. Electronic address: marinaantunes@feevale.br.
Clin Biochem ; 56: 18-25, 2018 Jun.
Article in En | MEDLINE | ID: mdl-29625079
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saliva / Uracil / Dihydrouracil Dehydrogenase (NADP) / Dihydropyrimidine Dehydrogenase Deficiency / Fluorouracil / Antimetabolites, Antineoplastic / Neutropenia Type of study: Prognostic_studies / Risk_factors_studies Limits: Aged80 Language: En Journal: Clin Biochem Year: 2018 Document type: Article Affiliation country: Brazil Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saliva / Uracil / Dihydrouracil Dehydrogenase (NADP) / Dihydropyrimidine Dehydrogenase Deficiency / Fluorouracil / Antimetabolites, Antineoplastic / Neutropenia Type of study: Prognostic_studies / Risk_factors_studies Limits: Aged80 Language: En Journal: Clin Biochem Year: 2018 Document type: Article Affiliation country: Brazil Country of publication: United States