Nitrate-promoted Selective C-H Fluorination of Benzamides and Benzeneacetamides.
Org Lett
; 20(8): 2445-2448, 2018 04 20.
Article
in En
| MEDLINE
| ID: mdl-29634276
ABSTRACT
A versatile and site-selective nitrate-promoted C-H bond fluorination using various weak coordinating amides as intrinsic directing groups was developed. Diverse tertiary and secondary amides underwent selective aromatic C-H bond fluorination, which features broad substrate scope, good regioselectivity, and mild conditions. Moreover, the late-stage C-H bond fluorination of the challenging benzeneacetamides via distal directing was reported for the first time.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2018
Document type:
Article