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A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology.
Phillips, Blaine W; Schlage, Walter K; Titz, Bjoern; Kogel, Ulrike; Sciuscio, Davide; Martin, Florian; Leroy, Patrice; Vuillaume, Gregory; Krishnan, Subash; Lee, Tom; Veljkovic, Emilija; Elamin, Ashraf; Merg, Celine; Ivanov, Nikolai V; Peitsch, Manuel C; Hoeng, Julia; Vanscheeuwijck, Patrick.
Affiliation
  • Phillips BW; PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore.
  • Schlage WK; Biology Consultant, Max-Baermann-Str. 21, 51429, Bergisch Gladbach, Germany.
  • Titz B; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland.
  • Kogel U; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland.
  • Sciuscio D; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland.
  • Martin F; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland.
  • Leroy P; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland.
  • Vuillaume G; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland.
  • Krishnan S; PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore.
  • Lee T; PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore.
  • Veljkovic E; PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Science Park II, Singapore.
  • Elamin A; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland.
  • Merg C; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland.
  • Ivanov NV; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland.
  • Peitsch MC; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland.
  • Hoeng J; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland.
  • Vanscheeuwijck P; PMI R&D, Philip Morris Products S.A., Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland. Electronic address: Patrick.Vanscheeuwijck@pmi.com.
Food Chem Toxicol ; 116(Pt B): 388-413, 2018 Jun.
Article in En | MEDLINE | ID: mdl-29654848
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory System / Smoke / Nicotiana / Carbon / Inhalation Exposure / Aerosols Type of study: Prognostic_studies Limits: Animals Language: En Journal: Food Chem Toxicol Year: 2018 Document type: Article Affiliation country: Singapore Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory System / Smoke / Nicotiana / Carbon / Inhalation Exposure / Aerosols Type of study: Prognostic_studies Limits: Animals Language: En Journal: Food Chem Toxicol Year: 2018 Document type: Article Affiliation country: Singapore Country of publication: United kingdom