Panduratin A induces protective autophagy in melanoma via the AMPK and mTOR pathway.

Lai, Siew-Li; Mustafa, Mohd Rais; Wong, Pooi-Fong

Lai, Siew-Li; Mustafa, Mohd Rais; Wong, Pooi-Fong.

Affiliation

Lai SL; Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
Mustafa MR; Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia; Center for Natural Products and Drug Research (CENAR), University of Malaya, Malaysia.
Wong PF; Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia. Electronic address: wongpf@um.edu.my.

Phytomedicine ; 42: 144-151, 2018 Mar 15.

Article in En | MEDLINE | ID: mdl-29655680

Subject(s)

AMP-Activated Protein Kinases/metabolism; Autophagy/drug effects; Chalcones/pharmacology; Melanoma/drug therapy; TOR Serine-Threonine Kinases/metabolism; Apoptosis/drug effects; Beclin-1/metabolism; Cell Line, Tumor; Humans; Melanoma/metabolism; Melanoma/pathology; Microtubule-Associated Proteins/metabolism; Sequestosome-1 Protein/metabolism; Signal Transduction/drug effects

Key words

AMPK; Autophagy; Panduratin A; mTOR

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Chalcones / AMP-Activated Protein Kinases / TOR Serine-Threonine Kinases / Melanoma Limits: Humans Language: En Journal: Phytomedicine Journal subject: TERAPIAS COMPLEMENTARES Year: 2018 Document type: Article Affiliation country: Malaysia Country of publication: Germany

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