Does matching for SNPs in the MHC gamma block in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant improve outcomes?
Hum Immunol
; 79(7): 532-536, 2018 Jul.
Article
in En
| MEDLINE
| ID: mdl-29660451
ABSTRACT
BACKGROUND:
Matching at the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci is important in donor selection for patients undergoing unrelated allogeneic hematopoietic stem cell transplantation (ASCT). Additional matching across the MHC gamma region may further improve outcomes.METHODS:
The MHC gamma region was retrospectively genotyped in 66 adult recipients of ASCT and their 10/10 matched unrelated donors. A chart review was performed to determine whether MHC gamma matching impacted survival, relapse, or graft-versus-host disease.RESULTS:
Of 66 donor-recipient pairs, 26(39.4%) were gamma-type matches, 34(51.5%) were mismatches, and 6(9.1%) were "indeterminate." Matching status was not associated with overall survival (pâ¯=â¯0.43), relapse (pâ¯=â¯0.21), acute GVHD (pâ¯=â¯0.43), severe aGVHD (pâ¯=â¯0.31), or chronic GVHD (pâ¯=â¯0.23) in univariate analyses, nor in multivariate analyses (pâ¯=â¯0.28, 0.13, 0.29, 0.16, and 0.67, respectively), with or without adjusting for HLA-DPB1 matching status.CONCLUSIONS:
In our single institution study, gamma-type matching status was not associated with outcomes of adult ASCT recipients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hematologic Neoplasms
/
Stem Cell Transplantation
/
Genotype
/
HLA Antigens
/
Major Histocompatibility Complex
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Hum Immunol
Year:
2018
Document type:
Article
Affiliation country:
United States