The rheumatic disease-associated FAM167A-BLK locus encodes DIORA-1, a novel disordered protein expressed highly in bronchial epithelium and alveolar macrophages.

Mentlein, L; Thorlacius, G E; Meneghel, L; Aqrawi, L A; Ramírez Sepúlveda, J I; Grunewald, J; Espinosa, A; Wahren-Herlenius, M

Mentlein, L; Thorlacius, G E; Meneghel, L; Aqrawi, L A; Ramírez Sepúlveda, J I; Grunewald, J; Espinosa, A; Wahren-Herlenius, M.

Affiliation

Mentlein L; Unit of Rheumatology.
Thorlacius GE; Unit of Rheumatology.
Meneghel L; Unit of Rheumatology.
Aqrawi LA; Unit of Rheumatology.
Ramírez Sepúlveda JI; Unit of Rheumatology.
Grunewald J; Respiratory Medicine Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Espinosa A; Unit of Rheumatology.
Wahren-Herlenius M; Unit of Rheumatology.

Clin Exp Immunol ; 193(2): 167-177, 2018 08.

Article in En | MEDLINE | ID: mdl-29663334

Subject(s)

Bronchi/physiology; Lung/metabolism; Macrophages, Alveolar/physiology; Proteins/genetics; Respiratory Mucosa/physiology; Rheumatic Diseases/genetics; Animals; Autoimmunity/genetics; Cloning, Molecular; Computational Biology; Conserved Sequence/genetics; Evolution, Molecular; Gene Expression Regulation/immunology; Genetic Loci/genetics; Humans; Mice, Inbred C57BL; Protein Conformation; Quantitative Trait Loci; Sequence Alignment; Unfolded Protein Response/genetics; src-Family Kinases/genetics

Key words

DIORA-1; DIORA-2; FAM167; Sjögren's syndrome; rheumatoid arthritis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bronchi / Proteins / Rheumatic Diseases / Macrophages, Alveolar / Respiratory Mucosa / Lung Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Clin Exp Immunol Year: 2018 Document type: Article Country of publication: United kingdom

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