Computational modeling of human oral bioavailability: what will be next?

Cabrera-Pérez, Miguel Ángel; Pham-The, Hai

Cabrera-Pérez, Miguel Ángel; Pham-The, Hai.

Affiliation

Cabrera-Pérez MÁ; a Unit of Modeling and Experimental Biopharmaceutics , Chemical Bioactive Center, Central University of Las Villas , Santa Clara , Cuba.
Pham-The H; b Department of Pharmacy and Pharmaceutical Technology , University of Valencia , Burjassot , Spain.

Expert Opin Drug Discov ; 13(6): 509-521, 2018 06.

Article in En | MEDLINE | ID: mdl-29663836

Subject(s)

Computer Simulation; Models, Biological; Pharmaceutical Preparations/administration & dosage; Administration, Oral; Animals; Biological Availability; Drug Development/methods; Drug Discovery/methods; Humans; Pharmaceutical Preparations/chemistry; Pharmaceutical Preparations/metabolism; Quantitative Structure-Activity Relationship; Reproducibility of Results

Key words

Oral bioavailability; computational ADME; drug development; drug discovery; oral absorption; physiologically based-pharmacokinetic model (PBPK); quantitative structure-property relationship (QSPR)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Computer Simulation / Pharmaceutical Preparations / Models, Biological Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Expert Opin Drug Discov Year: 2018 Document type: Article Affiliation country: Cuba Country of publication: United kingdom

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