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Sorafenib suppresses TGF-ß responses by inducing caveolae/lipid raft-mediated internalization/degradation of cell-surface type II TGF-ß receptors: Implications in development of effective adjunctive therapy for hepatocellular carcinoma.
Chung, Chih-Ling; Wang, Shih-Wei; Sun, Wei-Chih; Shu, Chih-Wen; Kao, Yu-Chen; Shiao, Meng-Shin; Chen, Chun-Lin.
Affiliation
  • Chung CL; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan, ROC.
  • Wang SW; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan, ROC.
  • Sun WC; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 81326, Taiwan, ROC.
  • Shu CW; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 81326, Taiwan, ROC.
  • Kao YC; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan, ROC.
  • Shiao MS; Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
  • Chen CL; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan, ROC; Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 80424, Taiwan, ROC. Electronic address: chunlinchen@mail.nsysu.edu.tw.
Biochem Pharmacol ; 154: 39-53, 2018 08.
Article in En | MEDLINE | ID: mdl-29678520
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transforming Growth Factor beta / Carcinoma, Hepatocellular / Caveolae / Membrane Microdomains / Sorafenib / Receptor, Transforming Growth Factor-beta Type II / Liver Neoplasms Limits: Animals / Humans / Male Language: En Journal: Biochem Pharmacol Year: 2018 Document type: Article Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transforming Growth Factor beta / Carcinoma, Hepatocellular / Caveolae / Membrane Microdomains / Sorafenib / Receptor, Transforming Growth Factor-beta Type II / Liver Neoplasms Limits: Animals / Humans / Male Language: En Journal: Biochem Pharmacol Year: 2018 Document type: Article Country of publication: United kingdom