miR-485-5p suppresses breast cancer progression and chemosensitivity by targeting survivin.
Biochem Biophys Res Commun
; 501(1): 48-54, 2018 06 18.
Article
in En
| MEDLINE
| ID: mdl-29678577
ABSTRACT
Breast cancer is the most common cancer among women worldwide. Chemoresistance remains to be a considerable obstacle in breast cancer therapy and it is often involves dysregulation of a variety of microRNAs (miRNAs). miR-485-5p functions as a tumor suppressor in several types of human cancers. However, its role in breast cancer chemosensitivity have not been determined. In the present study, we demonstrated that overexpression of miR-485-5p suppresses breast cancer progression and enhances chemosensitivity both in vitro and in vivo. Further study demonstrated that miR-485-5p directly targeted the 3'-untranslated region of survivin and overexpression of survivin overcomes the miR-485-5p induced effects on breast cancer. In conclusion, our study identified that miR-485-5p suppresses cancer progression and enhances the chemosensitivity by targeting survivin. Targeting survivin by miR-485-5p may provide a potential approach to reverse chemosensitivity in breast cancer cells.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
MicroRNAs
/
Inhibitor of Apoptosis Proteins
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
2018
Document type:
Article