A molecular dynamics simulation study decodes the Zika virus NS5 methyltransferase bound to SAH and RNA analogue.

Chuang, Chih-Hung; Chiou, Shean-Jaw; Cheng, Tian-Lu; Wang, Yeng-Tseng

Chuang, Chih-Hung; Chiou, Shean-Jaw; Cheng, Tian-Lu; Wang, Yeng-Tseng.

Affiliation

Chuang CH; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Chiou SJ; Department of Biochemistry, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Cheng TL; Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Wang YT; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Sci Rep ; 8(1): 6336, 2018 04 20.

Article in En | MEDLINE | ID: mdl-29679079

Subject(s)

Methyltransferases/genetics; Viral Nonstructural Proteins/metabolism; Zika Virus/genetics; Antiviral Agents/chemistry; Binding Sites; Crystallography, X-Ray; Methyltransferases/metabolism; Molecular Dynamics Simulation; Normal Distribution; Protein Binding; RNA/metabolism; RNA Cap Analogs/genetics; RNA Cap Analogs/metabolism; RNA-Dependent RNA Polymerase/metabolism; S-Adenosylhomocysteine/metabolism; Viral Nonstructural Proteins/ultrastructure; Zika Virus/metabolism; Zika Virus Infection/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Nonstructural Proteins / Zika Virus / Methyltransferases Language: En Journal: Sci Rep Year: 2018 Document type: Article Affiliation country: Taiwan Country of publication: United kingdom

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