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Field-deployable viral diagnostics using CRISPR-Cas13.
Myhrvold, Cameron; Freije, Catherine A; Gootenberg, Jonathan S; Abudayyeh, Omar O; Metsky, Hayden C; Durbin, Ann F; Kellner, Max J; Tan, Amanda L; Paul, Lauren M; Parham, Leda A; Garcia, Kimberly F; Barnes, Kayla G; Chak, Bridget; Mondini, Adriano; Nogueira, Mauricio L; Isern, Sharon; Michael, Scott F; Lorenzana, Ivette; Yozwiak, Nathan L; MacInnis, Bronwyn L; Bosch, Irene; Gehrke, Lee; Zhang, Feng; Sabeti, Pardis C.
Affiliation
  • Myhrvold C; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA. pardis@broadinstitute.org cmyhrvol@broadinstitute.org cfreije@broadinstitute.org.
  • Freije CA; Center for Systems Biology, Department of Organismal and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  • Gootenberg JS; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA. pardis@broadinstitute.org cmyhrvol@broadinstitute.org cfreije@broadinstitute.org.
  • Abudayyeh OO; Center for Systems Biology, Department of Organismal and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
  • Metsky HC; Ph.D. Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.
  • Durbin AF; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  • Kellner MJ; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
  • Tan AL; McGovern Institute for Brain Research, MIT, Cambridge, MA 02139, USA.
  • Paul LM; Department of Brain and Cognitive Science, MIT, Cambridge, MA 02139, USA.
  • Parham LA; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.
  • Garcia KF; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  • Barnes KG; McGovern Institute for Brain Research, MIT, Cambridge, MA 02139, USA.
  • Chak B; Department of Brain and Cognitive Science, MIT, Cambridge, MA 02139, USA.
  • Mondini A; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.
  • Nogueira ML; Department of Health Sciences and Technology, MIT, Cambridge, MA 02139, USA.
  • Isern S; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  • Michael SF; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA.
  • Lorenzana I; Ph.D. Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA.
  • Yozwiak NL; Institute for Medical Engineering and Science, MIT, Cambridge, MA 02139, USA.
  • MacInnis BL; Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  • Bosch I; Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA.
  • Gehrke L; Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA.
  • Zhang F; Centro de Investigaciones Genética, Instituto de Investigacion en Microbiologia, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras.
  • Sabeti PC; Centro de Investigaciones Genética, Instituto de Investigacion en Microbiologia, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras.
Science ; 360(6387): 444-448, 2018 04 27.
Article in En | MEDLINE | ID: mdl-29700266
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / RNA, Viral / Dengue / Dengue Virus / Endonucleases / Enzyme Assays / CRISPR-Associated Proteins / Zika Virus / Zika Virus Infection Type of study: Diagnostic_studies / Evaluation_studies / Guideline Limits: Humans Language: En Journal: Science Year: 2018 Document type: Article Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / RNA, Viral / Dengue / Dengue Virus / Endonucleases / Enzyme Assays / CRISPR-Associated Proteins / Zika Virus / Zika Virus Infection Type of study: Diagnostic_studies / Evaluation_studies / Guideline Limits: Humans Language: En Journal: Science Year: 2018 Document type: Article Country of publication: United States