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Polycyclic Sulfoximines as New Scaffolds for Drug Discovery.
Borst, Mark L G; Ouairy, Cécile M J; Fokkema, Sander C; Cecchi, Alessandro; Kerckhoffs, Jessica M C A; de Boer, Vincent L; van den Boogaard, Peter J; Bus, Rutger F; Ebens, Rijko; van der Hulst, Rob; Knol, Joop; Libbers, Rob; Lion, Zhou M; Settels, Bart W; de Wever, Ellen; Attia, Khaled A; Sinnema, Piet-Jan; de Gooijer, Jesse M; Harkema, Karen; Hazewinkel, Marieke; Snijder, Susan; Pouwer, Kees.
Affiliation
  • Borst MLG; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • Ouairy CMJ; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • Fokkema SC; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • Cecchi A; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • Kerckhoffs JMCA; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • de Boer VL; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • van den Boogaard PJ; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • Bus RF; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • Ebens R; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • van der Hulst R; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • Knol J; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • Libbers R; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • Lion ZM; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • Settels BW; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • de Wever E; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • Attia KA; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • Sinnema PJ; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • de Gooijer JM; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • Harkema K; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • Hazewinkel M; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • Snijder S; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
  • Pouwer K; Syncom B.V. , Kadijk 3 , 9747 AT Groningen , The Netherlands.
ACS Comb Sci ; 20(6): 335-343, 2018 06 11.
Article in En | MEDLINE | ID: mdl-29714998
ABSTRACT
The design and synthesis of three novel polycyclic scaffolds containing sulfoximines are presented in this work, which exemplify that sulfoximines represent a real opportunity for the discovery of new drug candidates. Additionally, the structures present at least two points of diversification and contain a high level of sp3-character, hence being very interesting 3D scaffolds. The compounds synthesized were added to the compound collection of the European Lead Factory.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polycyclic Compounds / Sulfoxides / Small Molecule Libraries Language: En Journal: ACS Comb Sci Year: 2018 Document type: Article Affiliation country: Netherlands
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polycyclic Compounds / Sulfoxides / Small Molecule Libraries Language: En Journal: ACS Comb Sci Year: 2018 Document type: Article Affiliation country: Netherlands