Development of a Small Molecule Tubulysin B Conjugate for Treatment of Carbonic Anhydrase IX Receptor Expressing Cancers.

Marks, Isaac S; Gardeen, Spencer S; Kurdziel, Sarah J; Nicolaou, Sonia T; Woods, J Evan; Kularatne, Sumith A; Low, Philip S

Marks, Isaac S; Gardeen, Spencer S; Kurdziel, Sarah J; Nicolaou, Sonia T; Woods, J Evan; Kularatne, Sumith A; Low, Philip S.

Affiliation

Kularatne SA; On Target Laboratories , West Lafayette , Indiana 47907 , United States.

Mol Pharm ; 15(6): 2289-2296, 2018 06 04.

Article in En | MEDLINE | ID: mdl-29715036

Subject(s)

Antineoplastic Agents/pharmacology; Carbonic Anhydrase IX/antagonists & inhibitors; Carbonic Anhydrase Inhibitors/pharmacology; Neoplasms/drug therapy; Oligopeptides/pharmacology; Pipecolic Acids/pharmacology; Animals; Antigens, Neoplasm/metabolism; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/therapeutic use; Carbonic Anhydrase IX/metabolism; Carbonic Anhydrase Inhibitors/chemical synthesis; Carbonic Anhydrase Inhibitors/therapeutic use; Cell Line, Tumor; Drug Design; Female; HEK293 Cells; Humans; Mice; Mice, Nude; Neoplasms/pathology; Oligopeptides/chemical synthesis; Oligopeptides/therapeutic use; Pipecolic Acids/chemical synthesis; Pipecolic Acids/therapeutic use; Xenograft Model Antitumor Assays

Key words

carbonic anhydrase IX; drug targeting; ligand-targeted therapy; small molecule drug conjugate; tubulysin chemotherapy; tumor-specific receptor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Pipecolic Acids / Carbonic Anhydrase Inhibitors / Carbonic Anhydrase IX / Neoplasms / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: Mol Pharm Journal subject: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Year: 2018 Document type: Article Country of publication: United States

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