Generation of a PAX6 knockout glioblastoma cell line with changes in cell cycle distribution and sensitivity to oxidative stress.

Hegge, Beate; Sjøttem, Eva; Mikkola, Ingvild

Hegge, Beate; Sjøttem, Eva; Mikkola, Ingvild.

Affiliation

Hegge B; Department of Pharmacy, Research Group of Pharmacology, University of Tromsø - The Arctic University of Norway, 9037, Tromsø, Norway.
Sjøttem E; Department of Medical Biology, Molecular Cancer Research Group, University of Tromsø - The Arctic University of Norway, 9037, Tromsø, Norway.
Mikkola I; Department of Pharmacy, Research Group of Pharmacology, University of Tromsø - The Arctic University of Norway, 9037, Tromsø, Norway. ingvild.mikkola@uit.no.

BMC Cancer ; 18(1): 496, 2018 05 02.

Article in En | MEDLINE | ID: mdl-29716531

Subject(s)

Brain Neoplasms/genetics; Brain Neoplasms/metabolism; Cell Cycle/genetics; Gene Knockout Techniques; Glioblastoma/genetics; Glioblastoma/metabolism; Oxidative Stress; PAX6 Transcription Factor/genetics; Antineoplastic Agents/pharmacology; Biomarkers; CRISPR-Cas Systems; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm/genetics; Gene Expression; Gene Targeting; Genes, Reporter; Genes, Tumor Suppressor; Humans

Key words

CRISPR-Cas9; Cell cycle; Colony-formation; Glioblastoma; Migration; Morphology; Oxidative stress; PAX6; Proliferation; U251

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Cell Cycle / Glioblastoma / Oxidative Stress / Gene Knockout Techniques / PAX6 Transcription Factor Type of study: Diagnostic_studies Limits: Humans Language: En Journal: BMC Cancer Journal subject: NEOPLASIAS Year: 2018 Document type: Article Affiliation country: Norway Country of publication: United kingdom

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