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Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells.
Iizuka-Ohashi, Mahiro; Watanabe, Motoki; Sukeno, Mamiko; Morita, Mie; Hoang, Ngoc Thi Hong; Kuchimaru, Takahiro; Kizaka-Kondoh, Shinae; Sowa, Yoshihiro; Sakaguchi, Koichi; Taguchi, Tetsuya; Sakai, Toshiyuki.
Affiliation
  • Iizuka-Ohashi M; Department of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Watanabe M; Division of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Sukeno M; Department of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Morita M; Department of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Hoang NTH; Department of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Kuchimaru T; Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
  • Kizaka-Kondoh S; Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
  • Sowa Y; Department of Life Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
  • Sakaguchi K; Department of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Taguchi T; Division of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Sakai T; Division of Endocrine and Breast Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Oncotarget ; 9(28): 19597-19612, 2018 Apr 13.
Article in En | MEDLINE | ID: mdl-29731968
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Oncotarget Year: 2018 Document type: Article Affiliation country: Japan Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Oncotarget Year: 2018 Document type: Article Affiliation country: Japan Country of publication: United States