Microbial transformation of pseudoprotodioscin by Gibberella fujikuroi.
J Asian Nat Prod Res
; 20(7): 624-632, 2018 Jul.
Article
in En
| MEDLINE
| ID: mdl-29732923
ABSTRACT
Three new (6, 9, and 12) and nine known steroidal saponins were obtained from the fermentation broth of pseudoprotodioscin (PPD) incubated with a fungus Gibberella fujikuroi CGMCC 3.4663. Structures of the metabolites were elucidated by 1-D (1H, 13C), 2-D (HMBC, HSQC, NOESY) NMR, and HR-MS analyses. The biotransformation pathway of pseudoprotodioscin by Gibberella fujikuroi CGMCC 3.4663 was proposed. Compounds 1-11 were tested in vitro for their cytotoxic activities against two human cancer cell lines (HepG2 and Hela). Compounds 1, 6, 9, and 10 exhibited cytotoxic activity against HepG2 cells. Compound 10 exhibited cytotoxicity to Hela cells.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diosgenin
/
Gibberella
Limits:
Humans
Language:
En
Journal:
J Asian Nat Prod Res
Journal subject:
BOTANICA
/
QUIMICA
Year:
2018
Document type:
Article
Affiliation country:
China