Potent leishmanicidal and antibacterial metabolites from Olea ferruginea.
J Asian Nat Prod Res
; 21(7): 679-687, 2019 Jul.
Article
in En
| MEDLINE
| ID: mdl-29733224
ABSTRACT
Inspired from the leishmanicidal and antibacterial potential of the fractions obtained from the crude extract of Olea ferruginea stem, the anti-leishmanial ethyl acetate fraction was subjected to chromatographic separation, leading to the isolation of a new compound ferruginan (1) and a known compound (+)- cycloolivil (2). The structures of 1 and 2 were determined by various spectroscopic techniques and were assayed for their in vitro antibacterial and leishmanicidal potential. Compound 1 showed 75% inhibition after 24 h of incubation and 98% inhibition after 48 h of incubation against Leishmania tropica KWH23 promastigotes at 100 µg/mL concentration, while compound 2 exhibited 73% and 96% inhibition at the same concentration and incubation time. Compound 1 also showed good activity against various bacterial pathogens.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leishmania tropica
/
Olea
/
Anti-Bacterial Agents
/
Antiparasitic Agents
Limits:
Animals
Language:
En
Journal:
J Asian Nat Prod Res
Journal subject:
BOTANICA
/
QUIMICA
Year:
2019
Document type:
Article
Affiliation country:
Pakistan
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM