Your browser doesn't support javascript.
loading
Design of Conformationally Constrained Acyl Sulfonamide Isosteres: Identification of N-([1,2,4]Triazolo[4,3- a]pyridin-3-yl)methane-sulfonamides as Potent and Selective hNaV1.7 Inhibitors for the Treatment of Pain.
Focken, Thilo; Chowdhury, Sultan; Zenova, Alla; Grimwood, Michael E; Chabot, Christine; Sheng, Tao; Hemeon, Ivan; Decker, Shannon M; Wilson, Michael; Bichler, Paul; Jia, Qi; Sun, Shaoyi; Young, Clint; Lin, Sophia; Goodchild, Samuel J; Shuart, Noah G; Chang, Elaine; Xie, Zhiwei; Li, Bowen; Khakh, Kuldip; Bankar, Girish; Waldbrook, Matthew; Kwan, Rainbow; Nelkenbrecher, Karen; Karimi Tari, Parisa; Chahal, Navjot; Sojo, Luis; Robinette, C Lee; White, Andrew D; Chen, Chien-An; Zhang, Yi; Pang, Jodie; Chang, Jae H; Hackos, David H; Johnson, J P; Cohen, Charles J; Ortwine, Daniel F; Sutherlin, Daniel P; Dehnhardt, Christoph M; Safina, Brian S.
Affiliation
  • Focken T; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Chowdhury S; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Zenova A; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Grimwood ME; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Chabot C; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Sheng T; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Hemeon I; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Decker SM; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Wilson M; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Bichler P; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Jia Q; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Sun S; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Young C; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Lin S; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Goodchild SJ; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Shuart NG; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Chang E; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Xie Z; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Li B; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Khakh K; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Bankar G; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Waldbrook M; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Kwan R; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Nelkenbrecher K; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Karimi Tari P; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Chahal N; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Sojo L; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Robinette CL; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • White AD; Chempartner , Building No. 5, 998 Halei Rd. , Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203 , China.
  • Chen CA; Chempartner , Building No. 5, 998 Halei Rd. , Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203 , China.
  • Zhang Y; Chempartner , Building No. 5, 998 Halei Rd. , Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203 , China.
  • Pang J; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Chang JH; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Hackos DH; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Johnson JP; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Cohen CJ; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Ortwine DF; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Sutherlin DP; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Dehnhardt CM; Xenon Pharmaceuticals, Inc. , 200-3650 Gilmore Way , Burnaby , BC V5G 4W8 , Canada.
  • Safina BS; Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
J Med Chem ; 61(11): 4810-4831, 2018 06 14.
Article in En | MEDLINE | ID: mdl-29737846
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Sulfonamides / Drug Design / NAV1.7 Voltage-Gated Sodium Channel / Voltage-Gated Sodium Channel Blockers Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: Canada Country of publication: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Sulfonamides / Drug Design / NAV1.7 Voltage-Gated Sodium Channel / Voltage-Gated Sodium Channel Blockers Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: Canada Country of publication: United States