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Sex Differences in the Subcellular Distribution of Corticotropin-Releasing Factor Receptor 1 in the Rat Hippocampus following Chronic Immobilization Stress.
McAlinn, Helena R; Reich, Batsheva; Contoreggi, Natalina H; Kamakura, Renata Poulton; Dyer, Andreina G; McEwen, Bruce S; Waters, Elizabeth M; Milner, Teresa A.
Affiliation
  • McAlinn HR; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
  • Reich B; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
  • Contoreggi NH; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
  • Kamakura RP; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
  • Dyer AG; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
  • McEwen BS; Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA.
  • Waters EM; Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA.
  • Milner TA; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA; Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA. Electronic address: tmilner@med.cornell.edu.
Neuroscience ; 383: 98-113, 2018 07 15.
Article in En | MEDLINE | ID: mdl-29753863
Corticotropin-releasing factor receptors (CRFR1) contribute to stress-induced adaptations in hippocampal structure and function that can affect learning and memory processes. Our prior studies showed that female rats with elevated estrogens compared to males have more plasmalemmal CRFR1 in CA1 pyramidal cells, suggesting a greater sensitivity to stress. Here, we examined the distribution of hippocampal CRFR1 following chronic immobilization stress (CIS) in female and male rats using immuno-electron microscopy. Without stress, total CRFR1 dendritic levels were higher in females in CA1 and in males in the hilus; moreover, plasmalemmal CRFR1 was elevated in pyramidal cell dendrites in CA1 in females and in CA3 in males. Following CIS, near-plasmalemmal CRFR1 increased in CA1 pyramidal cell dendrites in males but not to levels of control or CIS females. In CA3 and the hilus, CIS decreased cytoplasmic and total CRFR1 in dendrites in males only. These results suggest that in naive rats, CRF could induce a greater activation of CA1 pyramidal cells in females than males. Moreover, after CIS, which leads to even greater sex differences in CRFR1 by trafficking it to different subcellular compartments, CRF could enhance activation of CA1 pyramidal cells in males but to a lesser extent than either unstressed or CIS females. Additionally, CA3 pyramidal cells and inhibitory interneurons in males have heightened sensitivity to CRF, regardless of stress state. These sex differences in CRFR1 distribution and trafficking in the hippocampus may contribute to reported sex differences in hippocampus-dependent learning processes in baseline conditions and following chronic stress.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Psychological / Sex Characteristics / Receptors, Corticotropin-Releasing Hormone / Hippocampus Limits: Animals Language: En Journal: Neuroscience Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Psychological / Sex Characteristics / Receptors, Corticotropin-Releasing Hormone / Hippocampus Limits: Animals Language: En Journal: Neuroscience Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States