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Lanostane triterpenoids from Tricholoma pardinum with NO production inhibitory and cytotoxic activities.
Zhang, Shuai-Bing; Li, Zheng-Hui; Stadler, Marc; Chen, He-Ping; Huang, Ying; Gan, Xiao-Qing; Feng, Tao; Liu, Ji-Kai.
Affiliation
  • Zhang SB; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China; University of Chinese Academy of Sciences,
  • Li ZH; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, China.
  • Stadler M; Helmholtz Centre for Infection Research GmbH (HZI), Department Microbial Drugs, Inhoffenstraße 7, 38124, Braunschweig, Germany.
  • Chen HP; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, China.
  • Huang Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Gan XQ; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, China.
  • Feng T; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, China. Electronic address: tfeng@mail.scuec.edu.cn.
  • Liu JK; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, China. Electronic address: jkliu@mail.kib.ac.cn.
Phytochemistry ; 152: 105-112, 2018 Aug.
Article in En | MEDLINE | ID: mdl-29758519
ABSTRACT
Eight undescribed lanostane triterpenoids, pardinols A‒H, along with one previously reported lanostane triterpenoid, namely saponaceol B, were isolated from the fruiting bodies of Tricholoma pardinum. Their structures and stereoconfigurations were established via combination of extensive spectroscopic analyses, alkaline methanolysis method and TDDFT/ECD calculations. Pardinols B and E-H exhibited certain inhibition activities of nitric oxide (NO) production with IC50 value ranging from 5.3 to 14.7 µM, as well as cytotoxicities against human cancer cell-lines.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Fruiting Bodies, Fungal / Tricholoma / Macrophages / Antineoplastic Agents / Nitric Oxide Limits: Animals / Humans Language: En Journal: Phytochemistry Year: 2018 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Fruiting Bodies, Fungal / Tricholoma / Macrophages / Antineoplastic Agents / Nitric Oxide Limits: Animals / Humans Language: En Journal: Phytochemistry Year: 2018 Document type: Article