Probiotics and nutraceuticals as a new frontier in obesity prevention and management.
Diabetes Res Clin Pract
; 141: 190-199, 2018 Jul.
Article
in En
| MEDLINE
| ID: mdl-29772287
ABSTRACT
INTRODUCTION:
The beneficial interaction between the microbiota and humans is how bacteria contained within the gut 'talk' to the immune system and in this landscape, probiotics and nutraceuticals play a major role. The study aims to determine whether probiotics plus nutraceuticals such as smectite or omega-3 are superior to probiotic alone on the monosodium glutamate (MSG) induced obesity model in rats.METHODS:
Totally, 75 rats divided into five groups were included (nâ¯=â¯15, in each). Rats in group I were intact. Newborn rats in groups II-V were injected with MSG. Group III (Symbiter) received 2.5â¯ml/kg of multiprobiotic "Symbiter" containing concentrated biomass of 14 probiotic bacteria genera. Groups IV (Symbiter-Omega) and V (Symbiter-Smectite) received a combination of probiotic biomass supplemented with flax and wheat germ oil (250â¯mg of each, concentration of omega-3 fatty acids 1-5%) or smectite gel (250â¯mg), respectively.RESULTS:
In all interventional groups, significant reductions of total body and visceral adipose tissue weight as compared to MSG-obesity were observed. However, the lowest prevalence of obesity was noted for Symbiter-Omega (20% vs 33.3% as compared to other interventional groups). Moreover, supplementation of probiotics with omega-3 lead to a more pronounced decrease in HOMA-IR (2.31⯱â¯0.13 vs 4.02⯱â¯0.33, pâ¯<â¯0.001) and elevation of adiponectin levels (5.67⯱â¯0.39 vs 2.61⯱â¯0.27, Pâ¯<â¯0.001), compared to the obesity group.CONCLUSION:
Probiotics and nutraceuticals led to a significantly lower prevalence of obesity, reduction of insulin resistance, total and VAT weight. Our study demonstrated that supplementation of probiotics with omega-3 may have the most beneficial antiobesity properties.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Probiotics
/
Dietary Supplements
/
Obesity
Type of study:
Risk_factors_studies
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Diabetes Res Clin Pract
Journal subject:
ENDOCRINOLOGIA
Year:
2018
Document type:
Article