Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn.

Li, Chuanzhou; Götz, Jürgen

Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn.

Li, Chuanzhou; Götz, Jürgen.

Affiliation

Li C; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St Lucia Campus (Brisbane), QLD, Australia.
Götz J; Department of Medical Genetics, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

J Alzheimers Dis ; 64(1): 205-221, 2018.

Article in En | MEDLINE | ID: mdl-29782321

Subject(s)

Focal Adhesion Kinase 2/metabolism; Gene Expression Regulation/genetics; Proto-Oncogene Proteins c-fyn/metabolism; Adenosine Triphosphate/pharmacology; Animals; Disease Models, Animal; Disks Large Homolog 4 Protein/metabolism; Focal Adhesion Kinase 2/genetics; Gene Expression Regulation/drug effects; HEK293 Cells; Hippocampus/metabolism; Hippocampus/pathology; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins/metabolism; Mutation/genetics; Phosphorylation/genetics; Proto-Oncogene Proteins c-fyn/genetics; RNA, Messenger/metabolism; Tauopathies/genetics; Tauopathies/metabolism; Tauopathies/pathology; Transfection; tau Proteins/genetics; tau Proteins/metabolism

Key words

Alzheimer's disease; Fyn; Pyk2; tau; tau phosphorylation; tyrosine kinase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Focal Adhesion Kinase 2 / Proto-Oncogene Proteins c-fyn Limits: Animals / Humans Language: En Journal: J Alzheimers Dis Journal subject: GERIATRIA / NEUROLOGIA Year: 2018 Document type: Article Affiliation country: Australia Country of publication: Netherlands

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