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A monoclonal antibody targeting amyloid ß (Aß) restores complement factor I bioactivity: Potential implications in age-related macular degeneration and Alzheimer's disease.
Lashkari, Kameran; Teague, Gianna; Chen, Hong; Lin, Yong-Qing; Kumar, Sanjay; McLaughlin, Megan M; López, Francisco J.
Affiliation
  • Lashkari K; Schepens Eye Research Institute, Mass Eye & Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
  • Teague G; Schepens Eye Research Institute, Mass Eye & Ear, Harvard Medical School, Boston, Massachusetts, United States of America.
  • Chen H; Alliance Pharma, Malvern, Pennsylvania, United States of America.
  • Lin YQ; Alliance Pharma, Malvern, Pennsylvania, United States of America.
  • Kumar S; Alternative Discovery & Development, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America.
  • McLaughlin MM; Alternative Discovery & Development, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America.
  • López FJ; Alternative Discovery & Development, GlaxoSmithKline, King of Prussia, Pennsylvania, United States of America.
PLoS One ; 13(5): e0195751, 2018.
Article in En | MEDLINE | ID: mdl-29782502
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Amyloid beta-Peptides / Complement Factor I / Complement Activation / Alzheimer Disease / Macular Degeneration / Antibodies, Monoclonal Type of study: Observational_studies Limits: Aged / Female / Humans / Male Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biomarkers / Amyloid beta-Peptides / Complement Factor I / Complement Activation / Alzheimer Disease / Macular Degeneration / Antibodies, Monoclonal Type of study: Observational_studies Limits: Aged / Female / Humans / Male Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States