Tetramethylpyrazine attenuates lipopolysaccharide-induced cardiomyocyte injury via improving mitochondrial function mediated by 14-3-3Î³.

Huang, Bowei; You, Jiegeng; Qiao, Yang; Wu, Zelong; Liu, Dan; Yin, Dong; He, Huan; He, Ming

Huang, Bowei; You, Jiegeng; Qiao, Yang; Wu, Zelong; Liu, Dan; Yin, Dong; He, Huan; He, Ming.

Affiliation

Huang B; Jiangxi Medical School, Nanchang University, Nanchang 330006, China.
You J; Jiangxi Academy of Medical Sciences, Nanchang University, Nanchang 330006, China.
Qiao Y; Jiangxi Provincial Key Laboratory of Basic Pharmacology, Nanchang University School of Pharmaceutical Science, Nanchang 330006, China.
Wu Z; Jiangxi Provincial Key Laboratory of Basic Pharmacology, Nanchang University School of Pharmaceutical Science, Nanchang 330006, China.
Liu D; Jiangxi Provincial Key Laboratory of Basic Pharmacology, Nanchang University School of Pharmaceutical Science, Nanchang 330006, China.
Yin D; Jiangxi Provincial Key Laboratory of Molecular Medicine, the Second Affiliated Hospital, Nanchang University, Nanchang 330006, China.
He H; Jiangxi Provincial Key Laboratory of Basic Pharmacology, Nanchang University School of Pharmaceutical Science, Nanchang 330006, China. Electronic address: Hannahhe1988@hotmail.com.
He M; Jiangxi Provincial Key Laboratory of Basic Pharmacology, Nanchang University School of Pharmaceutical Science, Nanchang 330006, China.

Eur J Pharmacol ; 832: 67-74, 2018 Aug 05.

Article in En | MEDLINE | ID: mdl-29782860

Subject(s)

14-3-3 Proteins/metabolism; Lipopolysaccharides/pharmacology; Mitochondria/drug effects; Mitochondria/metabolism; Myocytes, Cardiac/cytology; Myocytes, Cardiac/drug effects; Pyrazines/pharmacology; Animals; Apoptosis/drug effects; Cell Survival/drug effects; Matrix Metalloproteinases/metabolism; Myocytes, Cardiac/metabolism; Phosphorylation/drug effects; Protein Transport/drug effects; Proto-Oncogene Proteins c-bcl-2/metabolism; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species/metabolism; Up-Regulation/drug effects; bcl-Associated Death Protein/metabolism

Key words

14-3-3Î³; Cardioprotection; Lipopolysaccharide; Mitochondrial function; Tetramethylpyrazine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Lipopolysaccharides / Myocytes, Cardiac / 14-3-3 Proteins / Mitochondria Limits: Animals Language: En Journal: Eur J Pharmacol Year: 2018 Document type: Article Affiliation country: China Country of publication: Netherlands

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