Pericytes in the Premetastatic Niche.
Cancer Res
; 78(11): 2779-2786, 2018 06 01.
Article
in En
| MEDLINE
| ID: mdl-29789421
ABSTRACT
The premetastatic niche formed by primary tumor-derived molecules contributes to fixation of cancer metastasis. The design of efficient therapies is limited by the current lack of knowledge about the details of cellular and molecular mechanisms involved in the premetastatic niche formation. Recently, the role of pericytes in the premetastatic niche formation and lung metastatic tropism was explored by using state-of-the-art techniques, including in vivo lineage-tracing and mice with pericyte-specific KLF4 deletion. Strikingly, genetic inactivation of KLF4 in pericytes inhibits pulmonary pericyte expansion and decreases metastasis in the lung. Here, we summarize and evaluate recent advances in the understanding of pericyte contribution to premetastatic niche formation. Cancer Res; 78(11); 2779-86. ©2018 AACR.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pericytes
/
Neoplasm Metastasis
Limits:
Animals
/
Humans
Language:
En
Journal:
Cancer Res
Year:
2018
Document type:
Article
Affiliation country:
Brazil