Effects of different periodontal treatments in changing the prevalence and levels of Archaea present in the subgingival biofilm of subjects with periodontitis: A secondary analysis from a randomized controlled clinical trial.
Int J Dent Hyg
; 16(4): 569-575, 2018 Nov.
Article
in En
| MEDLINE
| ID: mdl-29797436
ABSTRACT
OBJECTIVE:
The aim of this randomized double-blind and placebo-controlled study was to assess if periodontal treatment with or without systemic antibiotic would change the mean level of Archaea.METHODS:
Fifty-nine (59) subjects were randomly assigned to receive scaling and root planing (SRP) alone or combined with metronidazole (MTZ; 400 mg/TID) or either with MTZ and amoxicillin (AMX; 500 mg/TID) for 14 days. Clinical and microbiological examinations were performed at baseline and at 6 months post-SRP. Six subgingival plaque samples per subject were analysed for the presence and levels of Archaea using quantitative polymerase chain reaction.RESULTS:
Scaling and root planing alone or combined with MTZ or MTZ + AMX significantly reduced the prevalence of subjects colonized by Archaea at 6 months post-therapy, without significant differences among groups (P > .05). Both therapies led to a statistically significant decrease in the mean percentage of sites colonized by Archaea (P < .05). The MTZ and MTZ + AMX group had a significantly lower mean number of sites colonized by Archaea and lower levels of these micro-organisms at sites with probing depth ≥5 mm at 6 months compared with SRP group (P < .05).CONCLUSION:
Periodontal treatments including adjunctive MTZ or MTZ + AMX are more effective than mechanical treatment alone in reducing the levels and prevalence of sites colonized by Archaea in subjects with chronic periodontitis.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dental Scaling
/
Root Planing
/
Archaea
/
Biofilms
/
Dental Plaque
/
Chronic Periodontitis
/
Gingiva
/
Amoxicillin
/
Metronidazole
Type of study:
Clinical_trials
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Int J Dent Hyg
Journal subject:
ODONTOLOGIA
Year:
2018
Document type:
Article
Affiliation country:
Brazil