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Depsidomycins B and C: New Cyclic Peptides from a Ginseng Farm Soil-Derived Actinomycete.
Kwon, Yun; Byun, Woong Sub; Kim, Byung-Yong; Song, Myoung Chong; Bae, Munhyung; Yoon, Yeo Joon; Shin, Jongheon; Lee, Sang Kook; Oh, Dong-Chan.
Affiliation
  • Kwon Y; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. kisi2016@snu.ac.kr.
  • Byun WS; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. sky_magic@naver.com.
  • Kim BY; ChunLab, Inc., JW TOWER, Seocho-gu, Seoul 06725, Republic of Korea. greg6044@gmail.com.
  • Song MC; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea. smch517@ewha.ac.kr.
  • Bae M; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. baemoon89@snu.ac.kr.
  • Yoon YJ; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea. joonyoon@ewha.ac.kr.
  • Shin J; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. shinj@snu.ac.kr.
  • Lee SK; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. sklee61@snu.ac.kr.
  • Oh DC; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. dongchanoh@snu.ac.kr.
Molecules ; 23(6)2018 May 25.
Article in En | MEDLINE | ID: mdl-29799492
LC/MS-based chemical profiling of a ginseng farm soil-derived actinomycete strain, Streptomyces sp. BYK1371, enabled the discovery of two new cyclic heptapeptides, depsidomycins B and C (1 and 2), each containing two piperazic acid units and a formyl group at their N-terminus. The structures of 1 and 2 were elucidated by a combination of spectroscopic and chemical analyses. These new compounds were determined to possess d-leucine, d-threonine, d-valine, and S-piperazic acid based on the advanced Marfey's method and a GITC (2,3,4,6-tetra-O-acetyl-ß-d-glucopyranosyl isothiocyanate) derivatization of their hydrolysates, followed by LC/MS analysis. Depsidomycins B and C displayed significant antimetastatic activities against metastatic breast cancer cells (MDA-MB-231).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Soil Microbiology / Streptomyces / Antineoplastic Agents Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2018 Document type: Article Country of publication: Switzerland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Soil Microbiology / Streptomyces / Antineoplastic Agents Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2018 Document type: Article Country of publication: Switzerland