Relationship of Morphologic Changes in the Brain and Spinal Cord and Disease Symptoms with Cerebrospinal Fluid Hydrodynamic Changes in Patients with Chiari Malformation Type I.

ABSTRACT

BACKGROUND: Morphometric analysis or examination of symptoms in patients with Chiari malformation type I (CM-I) with various associations does not suffice for evaluation of surgical outcome of these patients. We assessed the relationship of morphologic changes in brain and spinal cord and disease symptoms with changes in cerebrospinal fluid (CSF) hydrodynamic parameters in patients with CM-I. METHODS: The study included 41 patients in 3 groups of CM-I, CM-I/occipitoatlantoaxial joint instability, and CM-I/tethered cord syndrome and 18 normal subjects. Phase-contrast magnetic resonance imaging and computational fluid dynamics analysis were done for all samples. RESULTS: Maximum CSF velocities and pressures in patients had an increase of 17.1%-23.2% and 41.5%-56.8%, respectively, compared with normal subjects. The data dispersion of maximum CSF velocity was >3.1 times that of the maximum pressure. Results showed that maximum CSF pressure is a more appropriate hydrodynamic parameter than maximum CSF velocity for assessing the condition of patients. Results also showed that CSF and PCF volumes had declined 57% and 11.3%, respectively, in CM-I. These declines were greater in CM-I than in the other 2 groups. CONCLUSIONS: Maximum CSF pressure regardless of the group the patients belonged to was similar in patients with symptoms of similar intensity. The correlation between maximum CSF pressure with CSF and PCF volumes decreased secondary to the disease. PCF volume was more favorable than CSF volume for assessing intensity of disease symptoms. Furthermore, in a constant pressure change, sensitivity of PCF volume in CM-I/occipitoatlantoaxial joint instability and CM-I/tethered cord syndrome groups was more than in the CM-I group.