Soluble CD163 as a Potential Biomarker in Systemic Sclerosis.
Dis Markers
; 2018: 8509583, 2018.
Article
in En
| MEDLINE
| ID: mdl-29805720
ABSTRACT
OBJECTIVE:
To evaluate the performance of serum and urinary sCD163 concentrations as possible biomarker in systemic sclerosis (SSc).METHODS:
Urine and serum samples were obtained from SSc patients and age- and sex-matched controls. Serum and urinary sCD163 concentrations were measured by commercially available ELISA kit. SSc patients were assessed following international guidelines. Cross-sectional analyses were performed.RESULTS:
Two hundred and three SSc patients were included. The control group consisted of 47 age- and sex-matched patients having noninflammatory diseases, mainly osteoporosis. Serum sCD163 levels were significantly higher in SSc patients compared with controls (mean ± SD 529 ± 251 versus 385 ± 153 ng/mL; p < 0.001). Urinary sCD163 concentrations were higher in SSc patients than controls, but this did not reach significance (236 ± 498 versus 176 ± 173 ng/mg uCr; p = 0.580). The sCD163 concentrations were not associated with clinical, laboratory, and instrumental characteristics of SSc patients.CONCLUSION:
To our knowledge, this is the first evaluation of both serum and urinary sCD163 levels in SSc. Our results show a significant difference for sera values that should be prioritized for further studies as compared to urinary measurements. Our results further support that the M2 macrophages/CD163 signaling system may play a role in the pathogenesis of SSc, although we could not identify a subset of SSc patients with higher concentrations.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Scleroderma, Systemic
/
Antigens, Differentiation, Myelomonocytic
/
Antigens, CD
/
Receptors, Cell Surface
Type of study:
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Dis Markers
Journal subject:
BIOQUIMICA
Year:
2018
Document type:
Article
Affiliation country:
France